Computer simulation of explicit proton translocation in cytochrome c oxidase: The D-pathway
نویسندگان
چکیده
منابع مشابه
Oxygen Reduction and Proton Translocation by Cytochrome C Oxidase
.............................................................................................................5 ABBREVIATIONS..................................................................................................6 LIST OF ORIGINAL PUBLICATIONS...............................................................7
متن کاملProton-pumping mechanism of cytochrome C oxidase.
Cytochrome c oxidase (CcO), as the terminal oxidase of cellular respiration, coupled with a proton-pumping process, reduces molecular oxygen (O(2)) to water. This intriguing and highly organized chemical process represents one of the most critical aspects of cellular respiration. It employs transition metals (Fe and Cu) at the O(2) reduction site and has been considered one of the most challeng...
متن کاملProtonmotive functions of cytochrome c oxidase in reconstituted vesicles. Influence of turnover rate on 'proton translocation'.
1. Oxidation of ferrocytochrome c by cytochrome c oxidase incorporated into proteoliposomes induces a transient acidification of the external medium. This change is dependent on the presence of valinomycin and can be abolished by carbonyl cyanide p-trifluoromethoxyphenylhydrazone or by nigericin. The H+/e- ratio for the initial acidification varies with the internal buffering capacity of the ve...
متن کاملProton pumping by cytochrome c oxidase.
Proton Pumping in Cotychrome c Oxidase by Jianxun Lu Advisor: Professor Marilyn Gunner Cytochrome c oxidase (CcO) is a large trans-membrane protein, which is the final enzyme in the respiratory electron transport chain in mitochondria or aerobic bacteria. It implements proton pumping through the mitochondrial membrane against the electrochemical gradient, by utilizing the chemical energy releas...
متن کاملOn the role of the K-proton transfer pathway in cytochrome c oxidase.
Cytochrome c oxidase is a membrane-bound enzyme that catalyzes the four-electron reduction of oxygen to water. This highly exergonic reaction drives proton pumping across the membrane. One of the key questions associated with the function of cytochrome c oxidase is how the transfer of electrons and protons is coupled and how proton transfer is controlled by the enzyme. In this study we focus on...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2005
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0408117102